But the thing with sleep … Fatigue and Yellow eyes: Common Related Medical Conditions It can also cause dryness, which can lead to eye infections. Eye Health. I Never Knew Yellow Eyes Were A Warning Sign Of THIS What Lack Of Sleep Does To Eyes - essilorusa.com Common Side Effects Eye Spasms: Also referred to as myokymia, eye spasms are common side effects of sleep deprivation. When tears aren’t able to lubricate your eyes, they get dry. A small new study in the journal Sleep shows that sleep-deprived faces look more, shall we say, weary -- in the form of redder and more swollen eyes, dark under-eye circles, more wrinkles and droopier eyelids -- than well-rested faces. sleep From the moment you wake up to the moment you go to bed, your eyes are always working. If you refer to “yellow” as in “dull” eyes, this could be due to nature of work, some lack of sleep, vitamins etc.